Microbial transformation of hypoestenone

Authors
El Sayed, KA
Citation
Ka. El Sayed, Microbial transformation of hypoestenone, J NAT PROD, 64(3), 2001, pp. 373-375
Citations number
11
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
3
Year of publication
2001
Pages
373 - 375
Database
ISI
SICI code
0163-3864(200103)64:3<373:MTOH>2.0.ZU;2-H
Abstract
Preparative-scale fermentation of hypoestenone (1) with Mucor ramannianus ( ATCC 9628) has resulted in the isolation of 8(9)alpha -epoxyhypoestenone (2 ) and the new metabolites 8(9)alpha -epoxy-12,13-anhydrohypoestenone (3), 1 7-hydroxyhypoestenone (4), 13 alpha ,18-dihydroxyhypoestenone (5), and 13 b eta ,18-dihydroxyhypoestenone (6). Structure elucidation of these metabolit es was based primarily on 1D and 2D NMR analyses.