Ruthenium-catalyzed intramolecular hydroamination of aminoalkynes

Authors
Kondo, T Okada, T Suzuki, T Mitsudo, T
Citation
T. Kondo et al., Ruthenium-catalyzed intramolecular hydroamination of aminoalkynes, J ORGMET CH, 622(1-2), 2001, pp. 149-154
Citations number
92
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANOMETALLIC CHEMISTRY
ISSN journal
0022328X → ACNP
Volume
622
Issue
1-2
Year of publication
2001
Pages
149 - 154
Database
ISI
SICI code
0022-328X(20010315)622:1-2<149:RIHOA>2.0.ZU;2-E
Abstract
Low-valent ruthenium complexes with a pi -acidic ligand, such as Ru(eta (6) -cot)(dmfm)(2) [cot = 1,3,5-cyclooctatriene, dmfm = dimethyl fumarate] and Ru-3(CO)(12), showed high catalytic activity for the intramolecular hydroam ination of aminoalkynes. The reaction is highly regioselective, in which a nitrogen atom is selectively attached to an internal carbon of alkynes to g ive five-, six-, and seven-membered nitrogen heterocycles as well as indole s in good to high yields. (C) 2001 Elsevier Science B.V. All rights reserve d.