E. Simon et al., Effects of medium-chain fatty acids on body composition and protein metabolism in overweight rats, J PHYSIOL B, 56(4), 2000, pp. 337-346
The lack of efficiency of classical treatments for obesity has led to propo
se alternative strategies. In order to obtain information about the effects
of dietary fatty acid composition on body fat and protein metabolism, over
weight female rats were fed on isoenergetic diets, using either medium-chai
n (MCT) or long-chain (LCT) triglycerides as a lipid source. After 23 days,
the MCT group had mildly decreased body weight but greatly reduced adipose
tissue depots. All far, depots were significantly diminished. MCT-fed rats
showed a decrease in some hormones involved in energy balance, such as lep
tin and triiodothyronine. Feeding MCT resulted in improvements in nitrogen
balance. Muscle protein content was similar in both treatments despite an i
ncrease in protein degradation in the MCT group. The present data clearly s
how that a diet with MCT as lipid fuel depresses weight gain and fat stores
, relative to a standard LCT diet.