We describe our technique for ultrasonographically guided fine-needle aspir
ation biopsy of the thyroid that achieves a high rate of diagnostic specime
ns. Indications for ultrasonographically guided fine-needle aspiration biop
sy included a difficult-to-palpate thyroid nodule and previously unsuccessf
ul palpation-guided fine-needle aspiration. Ultrasonographically guided fin
e-needle aspiration biopsy was performed on 316 thyroid nodules in 306 pati
ents. Adequate cytologic specimens were obtained in 97.2% of the nodules in
which biopsy was performed, with a 2.8% rate of inadequate cellularity Two
helpful aspects of this technique that were thought to improve the overall
diagnostic yield were the use of color and power Doppler "vascular mapping
" of the nodule just before biopsy and on-site cytologic control.