This study evaluates the potential role of high-resolution sonography and c
olor Doppler sonography in the evaluation of the lacrimal glands in Sjogren
syndrome. We examined 15 women (age range, 52-73 years) affected by Sjogre
n syndrome and 15 women with no history and signs of lacrimal disease (age
range, 47-75 years). The lacrimal glands were visualized bilaterally in 6 o
f 15 patients. The lacrimal artery was detectable in all patients; the resi
stive index Mras higher than normal (0.72 +/- 0.04). An abnormal Schirmer t
est was present in six of six patients with visible glands and in two of ni
ne patients with invisible glands xerophthalmia was present in six of six p
atients with visible glands and in four of nine patients with invisible gla
nds; high levels of serum immunoglobulins were present in six of six patien
ts with visible glands and in three of nine patients with invisible glands.
Sonography is able to provide noninvasively much of the information needed
by the clinician.