Cm. Sehgal et al., Quantitative vascularity of breast masses by Doppler imaging: Regional variations and diagnostic implications, J ULTR MED, 19(7), 2000, pp. 427-440
Seventy-four biopsy proven breast masses were imaged by color and power Dop
pler imaging to evaluate vascular pattern of malignant and benign breast ma
sses. The images were analyzed for vascularity. The measurements were made
over the entire mass as well as regionally at its core, at its periphery, a
nd in the tissue surrounding it. The surgical specimens were analyzed for m
icrovessel density. The diagnostic performance of Doppler sonographic vascu
larity indices was evaluated by receiver operating characteristic analysis.
The malignant masses were 14 to 54% more vascular than the benign masses.
Both types of masses were more vascular by ultrasonography than the tissue
surrounding them. Whereas benign masses were 2.2 times more vascular than t
he surrounding tissue, the malignant masses were 5.0 times more vascular. I
n a subset of patients the regional vascularity at the core, periphery, and
surrounding tissue by Doppler imaging exhibited a strong correlation (R-2
> 0.9) with the corresponding histologic microvessel density measurements.
Although the malignant masses exhibited a strong gradient in vascularity, c
ore, periphery, surrounding tissue, the benign masses had relatively unifor
m distribution of vascularity. The area under the receiver operating charac
teristic curve (A(z)) for the Doppler indices ranged from 0.56 +/- 0.07 to
0.65 +/- 0.07. A nonlinear analysis including age-specific values of Dopple
r indices improved the diagnostic performance to A(z) = 0.85 +/- 0.06. In c
onclusion, quantitative Doppler imaging when used in combination with a non
linear rule-based approach has the potential for differentiating between ma
lignant and benign masses.