Propagation of rat parvovirus in thymic lymphoma cell line C58(NT)D and subsequent appearance of a resistant cell clone after lytic infection

Authors
Ueno, Y Harada, T Iseki, H Ohshima, T Sugiyama, F Yagami, KI
Citation
Y. Ueno et al., Propagation of rat parvovirus in thymic lymphoma cell line C58(NT)D and subsequent appearance of a resistant cell clone after lytic infection, J VIROLOGY, 75(8), 2001, pp. 3965-3970
Citations number
26
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
8
Year of publication
2001
Pages
3965 - 3970
Database
ISI
SICI code
0022-538X(200104)75:8<3965:PORPIT>2.0.ZU;2-D
Abstract
Rat parvovirus (RPV) is nonpathogenic in rats but causes persistent lymphoc ytotropic infection. We found that RPV was propagated in rat thymic lymphom a cell line C58(NT)D and induced apoptosis. Interestingly, a resistant subc lone, C58(NT)D/R, from surviving cells after lytic infection had differenti ated phenotypic modifications, such as increased cell adherence, resistance to apoptosis, and suppressed tumorigenicity.