Incidental renal artery stenosis in peripheral vascular disease: A case for treatment?

Background. Renal artery stenosis (RAS) is frequently encountered as an inc idental finding in peripheral vascular disease. We assessed whether revascu larization is indicated to prevent the practical consequences of end-stage renal failure, that is, the need for renal replacement therapy. Methods. In a retrospective study, a cohort of consecutive patients was fol lowed who had undergone angiography 8 to 10 years previously for peripheral artery disease. Patients with untreated incidental RAS of greater than or equal to 50% diameter stenosis (68.8 +/- 9.8 years, mean +/- SD) were compa red with regard to the prevalence of renal replacement therapy to controls without RAS who were matched for age and gender. Results. RAS was present in 126 of 356 evaluable patients (33%). None of th ese patients required renal replacement therapy during the 10-year follow-u p. Serum creatinine values remained stable during follow-up. Conclusions. Incidental RAS is frequently seen in patients with peripheral vascular disease. If left untreated, incidental RAS seems not to result in end-stage renal failure or in a need for renal replacement therapy. Revascu larization with the aim to prevent end-stage renal failure seems less indic ated, and further prospective studies are indicated to elucidate this issue .