Apolipoprotein H is increased in type 2 diabetic patients with microalbuminuria

Background and Aim: Serum apolipoprotein H (Apo H) levels are increased in hyperlipidemic subjects and type 2 diabetics, but unknown in microalbuminur ia, another disorder with an increased cardiovascular risk. We looked to se e whether increased Apo H levels are associated with microalbuminuria in ty pe 2 diabetes. Methods and Results: Serum Apo H was calculated in 20 normoalbuminuric and 17 microalbuminuric type 2 diabetics matched for age, sex, body mass index (BMI), glycosylated haemoglobin, plasma lipids and duration of diabetes, an d also compared with 20 non-diabetic controls matched for age, sex, BMI and plasma lipids. Mean serum Apo H was significantly higher in the microalbum inuric patients (31.12 +/-1.58 SEM vs 25.25 +/-1.52 and 24.72 +/-0.99 mg/dL , p=0.003). Conclusion: Serum apo H levels are increased in type 2 diabetics with micro albuminuria. (C) 2000, Medikal Press.