A large-scale synthesis of enantiomerically pure cetirizine dihydrochloride using preparative chiral HPLC

Authors
Pflum, DA Wilkinson, HS Tanoury, GJ Kessler, DW Kraus, HB Senanayake, CH Wald, SA
Citation
Da. Pflum et al., A large-scale synthesis of enantiomerically pure cetirizine dihydrochloride using preparative chiral HPLC, ORG PROC R, 5(2), 2001, pp. 110-115
Citations number
4
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
5
Issue
2
Year of publication
2001
Pages
110 - 115
Database
ISI
SICI code
1083-6160(200103/04)5:2<110:ALSOEP>2.0.ZU;2-I
Abstract
Enantiomerically pure cetirizine can be prepared by preparative HPLC separa tion of cetirizine amide, The amide has an alpha value of 2.76 (USP resolut ion of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.