Positron emission tomography in pallido-ponto-nigral degeneration (PPND) family (frontotemporal dementia with parkinsonism linked to chromosome 17 and point mutation in tau gene)

Pallido-ponto-nigral degeneration (PPND) is a rapidly progressive disorder characterized by frontotemporal dementia with parkinsonism unresponsive to levodopa therapy. In this study, we have further characterized the regional abnormalities of cerebral function using PET with 6-[F-18]fluoro-L-dopa (F D), [C-11] raclopride (RAC), and 2-deoxy-2-fluoro-[F-18]-D-glucose (FDG). F D and RAC scans were performed in 3 patients-2 new patients and a previousl y reported asymptomatic at-risk individual who became symptomatic 2 years a fter the first FD scan. Cerebral glucose metabolism was studied by FDG in 2 other patients. In keeping with previous reports, there was a severe reduc tion of FD uptake, which affected both caudate and putamen to a similar deg ree in all 3 patients. RAC scans showed normal to elevated striatal D2-rece ptor binding in all patients. Cerebral glucose metabolism was globally redu ced (>2 SD below control mean) in one patient, with maximal involvement of frontal regions, and to a lesser degree in the other patient. Our study sho wed severe presynaptic dopaminergic dysfunction with intact striatal D2 rec eptors in PPND patients, implying that the dopa unresponsiveness is probabl y a result of pathology downstream to the striatum. The pattern of presynap tic dysfunction contrasts with that seen in idiopathic parkinsonism, where the putamen is affected more than the caudate nucleus. The pattern of gluco se hypometabolism correlates well with the presence of frontotemporal demen tia. (C) 2001 Elsevier Science Ltd. All rights reserved.