Background: Vagus nerve stimulation (VNS) has been shown to be efficacious
in the treatment of patients > 12 years of age with refractory partial epil
epsies and it is suggested that VNS should be considered as one of the trea
tment options for these patients.
Methods: Four patients had partial epilepsies and one had symptomatic gener
alized epilepsy. After observation of the baseline seizure frequency and th
e average seizure frequency for 3 months, the VNS system was implanted. The
reafter, seizure frequency, average seizure frequency of each seizure type
during the month just before the evaluation, seizure severity, side effects
and quality of life were recorded.
Results: In four of five patients, overall seizure frequency was reduced >
50% after VNS treatment. The seizure types that showed a > 50% reduction in
frequency were auras, focal clonic, generalized tonic clonic seizures, ast
atic, versive, hypomotor, generalized tonic and generalized clonic seizures
according to Luders' classification. In two patients, as major convulsive
seizures were reduced in number after VNS treatment, dialeptic seizures (no
n-convulsive seizure with lapse of consciousness) gradually appeared. In on
e patient without significant seizure reduction, quick recovery from postic
tal periods after generalized tonic seizure was seen after treatment. In on
e patient with generalized epilepsy, improvement of cognitive function was
reported by his guardians. After VNS, the number of antiepileptic drugs was
reduced from three to one in one patient. No significant adverse effects w
ere noted in any patients.
Conclusions: Our results suggest that VNS is well tolerated in young patien
ts with intractable epilepsies and it may be an important non-pharmacologic
treatment option for children with severe epilepsies who cannot tolerate m
edical therapy and/or are not candidates for epilepsy surgery.