PREGNANCY-INDUCED HYPERTENSION AND HYALINE-MEMBRANE DISEASE

Objectives: (1) To determine whether the incidence of hyaline membrane disease (HMD) is different among premature babies of pre-eclamptic wo men and those of normotensive controls; (2) to determine the relative risk (RR) of HMD according to the severity of pre-eclampsia and gestat ional age. Methods: A retrospective and prospective cohort of 271 pre- eclamptic women and 271 normotensive controls, with gestational age be tween 28 and 34 weeks was studied, including only singleton pregnancie s, live fetuses and well-documented gestational age. Exclusion criteri a were ruptured membranes > 24 h, other maternal diseases and previous use of corticosteroids. Statistical analysis included relative risk a nd multiple logistic regression model. Results: The RR of HMD for babi es of pre-eclamptic women was 0.96 (95% Cl: 0.78-1.17), and remained u nchanged after controlling for gestational age and multiple logistic r egression analysis. Conclusion: Preterm babies of pre-eclamptic mother s had the same probability of having HMD as newborns of normotensive m others. (C) 1997 International Federation of Gynecology and Obstetrics .