A methodology for the probabilistic assessment of regional exposure to
mercury is presented. The methodology is based on a multimedia model
of the atmospheric fate and transport of mercury over a continental sc
ale, and the aquatic simulation of the transformation and bioaccumulat
ion of mercury in lakes in the region of interest. A probabilistic app
roach allows one to take into account the spatial variability of envir
onmental characteristics and the variability of dose-related variables
(e.g., fish consumption, body weight) among individuals. The methodol
ogy is demonstrated for total mercury deposition in the Great Lakes re
gion of the U.S.