Wj. Gaine et al., Late operative site pain with isola posterior instrumentation requiring implant removal - Infection or metal reaction?, SPINE, 26(5), 2001, pp. 583-587
Objectives. To elucidate the cause of late operative site pain in six cases
of scoliosis managed with Isola posterior instrumentation that required re
moval of the implants.
Method. Microbiologic examination of wound swabs and enriched culture of op
erative tissue specimens was undertaken in all cases. Histologic study of t
he peri-implant membranes also was conducted.
Results. The presentation in all cases was similar: back pain appearing bet
ween 12-20 months after surgery, followed by a local wound swelling leading
to a wound sinus. In only one of these cases was the discharge positive fo
r bacterial growth. Implant removal was curative. Histologic examination of
tissue specimens revealed a neutrophil-rich granulation tissue reaction su
ggestive of an infective etiology despite the failure to isolate organisms.
Within the granulation tissue was metallic debris that varied from very sp
arse to abundant from fretting at the distal cross-connector junctions. A r
eview of recent literature describing similar problems suggests that late o
nset spinal pain is a real entity and a major cause of implant removal.
Conclusions. On reviewing the evidence for an infective etiology versus a m
etallurgic reaction etiology for these cases of late onset spinal pain, it
was concluded that a subacute low-grade implant infection was the main caus
e. Histologic findings would seem to confirm low-grade infection. There may
be more than one causative factor for late operative site pain, as it is p
ossible that fretting at cross connection junctions may provide the environ
ment for the incubation of dormant or inactive microbes.