The sample size for a clinical trial: A Bayesian-decision theoretic approach

Authors
Halpern, J Brown, BW Hornberger, J
Citation
J. Halpern et al., The sample size for a clinical trial: A Bayesian-decision theoretic approach, STAT MED, 20(6), 2001, pp. 841-858
Citations number
24
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
STATISTICS IN MEDICINE
ISSN journal
02776715 → ACNP
Volume
20
Issue
6
Year of publication
2001
Pages
841 - 858
Database
ISI
SICI code
0277-6715(20010330)20:6<841:TSSFAC>2.0.ZU;2-C
Abstract
Using decision theory, what is an appropriate sample size for a clinical tr ial, with a binary endpoint? We present a program, suitable for actual plan ning, which, with some extensions, implements Canner's solution to this que stion. Examples with a discussion are given. Implications of a Bayesian app roach are discussed. Bayesian and Neyman-Pearson approaches are compared. C opyright (C) 2001 John Wiley & Sons, Ltd.