Y. Yavuz et al., Effect of increased intraabdominal pressure on cardiac output and tissue blood flow assessed by color-labeled microspheres in the pig, SURG ENDOSC, 15(2), 2001, pp. 149-155
Citations number
33
Categorie Soggetti
Surgery
Journal title
SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES
Background: Studies of the hemodynamic effects associated with the pneumope
ritoneum have had controversial results. We set out to investigate the effe
ct of increased intraabdominal pressure (IAP) on cardiac output and tissue
blood flow in Various intraabdominal and extraabdominal organs using the co
lor-labeled microsphere (CLM) technique.
Methods: IAP was induced by CO2 insufflation in anesthetized pigs; 0, 5, an
d 10 mmHg was used in the low-pressure group and 0, 15, and 24 mmHg in the
high-pressure group. Tissue blood flow (ml.min(-1).g(-1)) and cardiac outpu
t (CO) (ml/min) were determined by the CLM technique.
Results: CO decreased at IAP greater than or equal to 15 mmHg. Arterial PaC
O2 and hydrogen ion concentration increased in response to all levels of IA
P. Arterial PaO2, oxygen saturation, and bicarbonate ion concentration rema
ined unchanged. Low IAP did not influence tissue blood flows in most of the
organs. However, in the spleen, pancreas, esophagus, and gastric mucosal s
pecimens, tissue blood flow was significantly decreased at 24 mmHg.
Conclusion: The level of IAP used in current practice (10-12 mmHg) appears
to be safe with regard to hemodynamic variables and tissues blood flow; how
ever, higher levels may induce a decrease in cardiac output and tissue bloo
d flow.