Synthesis of 3-alkyl-1-isoindolinones by alkylation of a benzotriazolyl substituted N-dimethylamino-phthalimidine

Authors
Deniau, E Enders, D
Citation
E. Deniau et D. Enders, Synthesis of 3-alkyl-1-isoindolinones by alkylation of a benzotriazolyl substituted N-dimethylamino-phthalimidine, TETRAHEDRON, 57(13), 2001, pp. 2581-2588
Citations number
60
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
13
Year of publication
2001
Pages
2581 - 2588
Database
ISI
SICI code
0040-4020(20010326)57:13<2581:SO3BAO>2.0.ZU;2-H
Abstract
A convenient and versatile synthesis of 3-alkyl-2,3-dihydro-1H-isoindol-1-o nes (isoindolinones) based upon sequential metalation, alkylation alpha to nitrogen and C,N-deprotection from 3-benzotriazolyl-2-dimethylamino-phthali midine is described. (C) 2001 Elsevier Science Ltd. All rights reserved.