Solid-phase synthesis of peptide aldehydes directly on acetal resin

Authors
Yao, W Xu, HY
Citation
W. Yao et Hy. Xu, Solid-phase synthesis of peptide aldehydes directly on acetal resin, TETRAHEDR L, 42(13), 2001, pp. 2549-2552
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
13
Year of publication
2001
Pages
2549 - 2552
Database
ISI
SICI code
0040-4039(20010326)42:13<2549:SSOPAD>2.0.ZU;2-C
Abstract
A practical strategy for solid-phase synthesis of peptide aldehydes has bee n developed employing a 10,11-dihydroxy-undecanoic acid (DHUA) functionaliz ed resin. High loading levels are obtained for amino aldehydes as their res pective acetals. After classical Fmoc SPPS, treatment of the derivatized re sin with 95% TFA/H2O affords peptide aldehydes in high yield and purity. (C ) 2001 Elsevier Science Ltd. All rights reserved.