Synthesis of a modified thymidine monomer for site-specific incorporation of reporter groups into oligonucleotides

Authors
Brown, LJ May, JP Brown, T
Citation
Lj. Brown et al., Synthesis of a modified thymidine monomer for site-specific incorporation of reporter groups into oligonucleotides, TETRAHEDR L, 42(13), 2001, pp. 2587-2591
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
13
Year of publication
2001
Pages
2587 - 2591
Database
ISI
SICI code
0040-4039(20010326)42:13<2587:SOAMTM>2.0.ZU;2-S
Abstract
The efficient incorporation of reporter groups into oligonucleotides at spe cific sites has been facilitated by the synthesis of a novel modified thymi dine monomer with an FMOC-protected hydroxyl group on a linker. The primary hydroxyl group can be deprotected during or after solid-phase oligonucleot ide synthesis and reacted with any reporter phosphoramidite. (C) 2001 Elsev ier Science Ltd. All rights reserved.