Asymmetric synthesis of (R)-(-)-chlozolinate through a chemoenzymatic procedure

Authors
Guanti, G Banfi, L Powles, K Rasparini, M Scolastico, C Fossati, N
Citation
G. Guanti et al., Asymmetric synthesis of (R)-(-)-chlozolinate through a chemoenzymatic procedure, TETRAHEDR-A, 12(2), 2001, pp. 271-277
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
2
Year of publication
2001
Pages
271 - 277
Database
ISI
SICI code
0957-4166(20010219)12:2<271:ASO(TA>2.0.ZU;2-R
Abstract
A new asymmetric synthesis of (R)-chlozolinate 1, an important antifungal a gent, based on the enzymatic asymmetrization of diethyl 2-benzyloxy-2-methy lmalonate, is reported. (C) 2001 Elsevier Science Ltd. All rights reserved.