L. Burnham et al., Calculation of the vapor pressure-temperature relationship using thermogravimetry for the drug allopurinol, THERMOC ACT, 367, 2001, pp. 15-22
Allopurinol sublimates when subjected to thermogravimetry in a nitrogen atm
osphere. The process is zero order and plots of in k venus reciprocal tempe
rature (K) give a value of 132.64 kJ mol(-1) for the activation energy. On
the basis that equilibrium is achieved at all temperatures the data is used
to establish a plot of the vapor pressure curve versus temperature from wh
ich a Clausius-Clapeyron relationship can be used to establish the DeltaH f
or sublimation. The method requires that the equipment is calibrated and da
ta for p-aminobenzoic acid is used for this purpose. (C) 2001 Elsevier Scie
nce B.V. All rights reserved.