A case of renal involvement in persistent immune activation caused by chlamydial salpingitis

A 24-year-old woman presented with renal insufficiency, macrohematuria, and mild urinary protein. Polyclonal hypergamma-globulinemia, thrombocytosis, increased concentration of serum, and urinary interleukin (IL)-6 all indica ted persistent immune activation caused by a Chlamydia trachomatis infectio n of the fallopian tube. Gynecological treatment with levofloxacin was effe ctive both for the renal symptoms and other immunological parameters. First and second renal biopsy specimens showed an immune-complex glomerulopathy with extensive interstitial infiltration of many types of inflammatory cell s, including plasma cells. Thus, we conclude that chlamydial salpingitis mu st be considered as one causative disease factor for renal involvement by m eans of its persistent immune activation effects.