Metabolism of N-isopropylacetanilide in rat

1. Radioactivity from oral doses of nr-isopropyl[1-C-14]acetanilide was exc reted in urine (53.5%), faeces (8.1%) and expired air (17.0%) of rat. 2. Enterohepatic circulation occurred during formation of similar to 34% of the metabolites. N-isopropyracetanilide was metabolized by oxidation in al l moieties of the molecule with subsequent conjugation with glucuronic and sulphuric acids. 3. The sulphate ester of 4'-hpdroxyacetanilide (acetaminophen) was the majo r metabolite (28% of the dose).