Severe eosinophilia may be complicated by acute or chronic visceral damage.
The underlying origin of the hypereosinophilia may be infectious, allergic
, toxic, malignant or systemic (the secondary or reactive hypereosinophilic
syndrome), but in a number of cases no cause can be found (the idiopathic
hypereosinophilic syndrome).
We describe 4 cases with hypereosinophilia and secondary visceral damage af
ter residence in a tropical region. In three cases a helminthic infection w
as the obvious cause, the brain and the heart were the target organs. After
treatment of the infection both the hypereosinophilia and the neurological
and cardiac lesions disappeared. The fourth patient died of multi-organ di
sease. No definite trigger of the hypereosinophilia could be found.
We discuss clinical findings, necessary investigations and therapeutic stra
tegies.