Cancer of the nasal cavity and paranasal sinuses is a rare disease. The man
y different histologies and sites make the management of this disease a cha
llenge. The current report from the Danish Society for Head and Neck Oncolo
gy comprises a joint analysis of five retrospective series covering the ent
ire country, with 315 patients seen in the 10-year period from 1 January 19
82 to 31 December 1991. Tumour sites were nasal cavity (n = 156), maxillary
sinus (n = 139), ethmoid sinus (n = 14), sphenoid sinus (n = 5) and fronta
l sinus (one case). The most common histologies included squamous cell carc
inoma (126 cases); adenocarcinoma (41 cases), malignant melanoma (38 cases)
and malignant lymphoma (34 cases). A total of 284 patients (90%) received
treatment with curative intent; most of these patients were treated with ra
diotherapy, either alone (120 patients) or in combination with surgery (111
patients). There was no significant difference between the five centres in
disease specific survival and overall survival. The results showed that hi
stology, localization and nodal involvement were significant prognostic fac
tors for locoregional control and survival. Patients with squamous cell car
cinoma had a significantly poorer prognosis compared with patients with ade
nocarcinoma. However, a Cox multivariate analysis revealed that this was li
kely the result of tumour localization, as most adenocarcinomas were in the
nasal cavity. The experience from this data collection has inspired the Da
nish Society for Head and Neck Oncology to arrange common data registration
of several other clinical head and neck series. In the future, the Society
plans to expand this activity Further.