Frequency of triggering bacteria in patients with reactive arthritis and undifferentiated oligoarthritis and the relative importance of the tests used for diagnosis
C. Fendler et al., Frequency of triggering bacteria in patients with reactive arthritis and undifferentiated oligoarthritis and the relative importance of the tests used for diagnosis, ANN RHEUM D, 60(4), 2001, pp. 337-343
Objective-Reactive arthritis (ReA) triggered by Chlamydia trachomatis or en
teric bacteria such as yersinia, salmonella, Campylobacter jejuni, or shige
lla is an important differential diagnosis in patients presenting with the
clinical picture of an undifferentiated oligoarthritis (UOA). This study wa
s undertaken to evaluate the best diagnostic approach.
Patients and methods-52 patients with ReA, defined by arthritis and a sympt
omatic preceding infection of the gut or the urogenital tract, and 74 patie
nts with possible ReA, defined by oligoarthritis without a preceding sympto
matic infection and after exclusion of other diagnoses (UOA), were studied.
The following diagnostic tests were applied for the identification of the
triggering bacterium: for yersinia induced ReA-stool culture, enzyme immuno
assay (EIA), and Widal's agglutination test for detection of antibodies to
yersinia; for salmonella or campylobacter induced ReA-stool culture, EIA fo
r the detection of antibodies to salmonella and Campylobacter jejuni; for i
nfections with shigella-stool culture; for infections with Chlamydia tracho
matis-culture of the urogenital tract, microimmunofluorescence and immunope
roxidase assay for the detection of antibodies to Chlamydia trachomatis.
Results-A causative pathogen was identified in 29/52 (56%) of all patients
with ReA. In 17 (52%) of the patients with enteric ReA one of the enteric b
acteria was identified: salmonella in 11/33 (33%) and yersinia in 6/33 (18%
). Chlamydia trachomatis was the causative pathogen in 12/19 (63%) of the p
atients with urogenic ReA. In patients with the clinical picture of UOA a s
pecific triggering bacterium was also identified in 35/74 (47%) patients: y
ersinia in 14/74 (19%), salmonella in 9/74 (12%), and Chlamydia trachomatis
in 12/74 (16%).
Conclusions-Chlamydia trachomatis, yersinia, and salmonella can be identifi
ed as the causative pathogen in about 50% of patients with probable or poss
ible ReA if the appropriate tests are used.