An efficient batch preparation of high specific activity [I-123] and [I-124] mIBG

The increasing demand for radiolabeled metaiodobenzylguanidine (mIBG) promp ted the need to obtain the radiopharmaceutical by a reliable, routine and s imple synthetic method for batch production. The production of mIBG labeled with either I-123 or I-124 has been optimized by modifying literature meth ods that involve solid-state exchange reaction on "cold" mIBG facilitated b y ammonium sulfate. The radiochemical yield and purity of radioiodinated mI BG generally exceeded 80 and 98%, respectively, with specific activity of > 50 mCi/mg. (C) 2001 Elsevier Science Ltd. All rights reserved.