Optimisation of cyclotron production parameters for the Bi-209(alpha, 2n) At-211 reaction related to biomedical use of At-211

Authors
Henriksen, G Messelt, S Olsen, E Larsen, RH
Citation
G. Henriksen et al., Optimisation of cyclotron production parameters for the Bi-209(alpha, 2n) At-211 reaction related to biomedical use of At-211, APPL RAD IS, 54(5), 2001, pp. 839-844
Citations number
31
Categorie Soggetti
Multidisciplinary
Journal title
APPLIED RADIATION AND ISOTOPES
ISSN journal
09698043 → ACNP
Volume
54
Issue
5
Year of publication
2001
Pages
839 - 844
Database
ISI
SICI code
0969-8043(200105)54:5<839:OOCPPF>2.0.ZU;2-D
Abstract
The cyclotron alpha beam production of At-211 and of the contaminant At-210 related to beam energy were studied. Radiochemical purification of At-211 from the other main contaminant, Po-210, by an extraction procedure was als o evaluated. To avoid impurities 28 MeV has previously been considered as a maximum beam energy, but by using instead 29.1 MeV as a limit a large incr ease in EOB yield and sufficient radiochemical purity of extracted At-211 w ere obtained. More cyclotrons could thereby deliver quantities useful for c linical cancer trials. (C) 2001 Elsevier Science Ltd. All rights reserved.