SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N ONNATURAL AGLYCONES OF GLYCOPEPTIDE ANTIBIOTICS OF THE VANCOMYCIN GROUP

A new approach for the modification of the heptapeptide core of glycop eptide antibiotics was proposed based on the replacement of amino acid residues in positions 1 and 3 in teicoplanin aglycone and in position 1 in the eremomycin aglycone. Six novel nonnatural aglycones of the v ancomycin type were obtained. Compounds derived from the teicoplanin a glycone exhibited in vitro activity against Gram-positive bacteria, an d two of them were also active against the vancomycin-resistant entero cocci.