The molecular machinery for lysosome biogenesis

The lysosome serves as a site for delivery of materials targeted for remova l from the eukaryotic cell. The mechanisms underlying the biogenesis of thi s organelle are currently the subject of renewed interest due to advances i n our understanding of the protein sorting machinery. Genetic model systems such as yeast and Drosophila have been instrumental in identifying both pr otein and lipid components of this machinery. Importantly, many of these co mponents, as well as the processes in which they are involved, are proving conserved in mammals. Other recently identified components, however, appear to be unique to higher eukaryotes. Published 2001 John Wiley & Sons, Inc.d agger