2,4-thiazolidinediones as potent and selective human beta(3) agonists

Authors
Hu, BH Ellingboe, J Gunawan, I Han, S Largis, E Li, ZA Malamas, M Mulvey, R Oliphant, A Sum, FW Tillett, J Wong, V
Citation
Bh. Hu et al., 2,4-thiazolidinediones as potent and selective human beta(3) agonists, BIOORG MED, 11(6), 2001, pp. 757-760
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
6
Year of publication
2001
Pages
757 - 760
Database
ISI
SICI code
0960-894X(20010326)11:6<757:2APASH>2.0.ZU;2-B
Abstract
Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50 = 0.01 muM, IA = 1.19) and selective (more than 110-fold over beta (1) and b eta (2) agonist activity) beta (3) agonist. This compound has also been pro ven to be active and selective in an in vivo mode. (C) 2001 Elsevier Scienc e Ltd. All rights reserved.