Rl. Beard et al., Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity, BIOORG MED, 11(6), 2001, pp. 765-768
Retinoids are natural and synthetic analogues of the hormone retinoic acid.
Systemic retinoid agonist therapy is usually associated with toxic side ef
fects, such as mucocutaneous toxicity, which may be alleviated by the use o
f topical retinoid antagonists. We report the synthesis and biological acti
vity of a new series of potent, RAR-specific antagonists substituted with p
henyl cyclohexene and phenylcyclohexadiene groups. (C) 2001 Elsevier Scienc
e Ltd. All rights reserved.