The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin

Authors
Murray, PJ Kranz, M Ladlow, M Taylor, S Berst, F Holmes, AB Keavey, KN Jaxa-Chamiec, A Seale, PW Stead, P Upton, RJ Croft, SL Clegg, W Elsegood, MRJ
Citation
Pj. Murray et al., The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin, BIOORG MED, 11(6), 2001, pp. 773-776
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
6
Year of publication
2001
Pages
773 - 776
Database
ISI
SICI code
0960-894X(20010326)11:6<773:TSOCTA>2.0.ZU;2-H
Abstract
A novel synthetic strategy is described which may be used to prepare analog ues of the antimalarial, fungal metabolite apicidin. Compared to the natura l product, one analogue shows potent and selective activity in vitro agains t the parasite Trypanosoma brucei and low mammalian cell toxicity. (C) 2001 Elsevier Science Ltd. All rights reserved.