NO-independent stimulators of soluble guanylate cyclase

Authors
Straub, A Stasch, JP Alonso-Alija, C Benet-Buchholz, J Ducke, B Feurer, A Furstner, C
Citation
A. Straub et al., NO-independent stimulators of soluble guanylate cyclase, BIOORG MED, 11(6), 2001, pp. 781-784
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
6
Year of publication
2001
Pages
781 - 784
Database
ISI
SICI code
0960-894X(20010326)11:6<781:NSOSGC>2.0.ZU;2-I
Abstract
SARs around a novel type of guanylate cyclase stimulator which act by a mec hanism different from classical NO-donors are described. Several pyrazolopy ridinylpyrimidines are shown to relax aortic rings and revealed a long-last ing blood pressure lowering effect in rats after oral application. (C) 2001 Elsevier Science Ltd. All rights reserved.