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ENG
Synthesis of metabolically blocked paclitaxel analogues
Authors
Wittman, MD
Altstadt, TJ
Fairchild, C
Hansel, S
Johnston, K
Kadow, JF
Long, BH
Rose, WC
Vyas, DM
Wu, MJ
Zoeckler, ME
Citation
Md. Wittman et al., Synthesis of metabolically blocked paclitaxel analogues, BIOORG MED, 11(6), 2001, pp. 809-810
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X →
ACNP
Volume
11
Issue
6
Year of publication
2001
Pages
809 - 810
Database
ISI
SICI code
0960-894X(20010326)11:6<809:SOMBPA>2.0.ZU;2-G
Abstract
The stereospecific syntheses of the metabolically blocked 6-alpha -F, Cl, B r paclitaxel, and 6-alpha -F-10-acetyldocetaxel are described and in vitro and in vivo activity is presented. (C) 2001 Elsevier Science Ltd. All right s reserved.