Spatial requirements of the antagonist binding site of the NK2 receptor

Authors
Ali, MA Bhogal, N Fishwick, CWG Findlay, JBC
Citation
Ma. Ali et al., Spatial requirements of the antagonist binding site of the NK2 receptor, BIOORG MED, 11(6), 2001, pp. 819-822
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
6
Year of publication
2001
Pages
819 - 822
Database
ISI
SICI code
0960-894X(20010326)11:6<819:SROTAB>2.0.ZU;2-Y
Abstract
Computer-aided modelling has been used to identify a putative antagonist bi nding site in the tachykinin NK2 receptor. In order to validate the implied spatial requirements for this region, a series of compounds, based on the potent antagonist GR 149861 have been synthesised and their binding affinit ies established. Our findings suggest the presence of a large hydrophobic c avity in the putative binding crevice of GR 149861. (C) 2001 Elsevier Scien ce Ltd. All rights reserved.