Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs

Modafinil did not affect spontaneous and K+-evoked [H-3]5-HT efflux from co rtical synaptosomes while it increased K+-evoked tritium efflux from cortic al slices, an action that became stronger in the presence of paroxetine. In contrast, DL-fenfluramine and fluoxetine were able to enhance spontaneous and/or K+-evoked tritium efflux from synaptosomes and slices. These results suggest that modafinil does not affect 5-HT transmission from cortical syn aptosomes and that its 5-HT releasing action is different from that of DL-f enfluramine and fluoxetine. (C) 2001 Elsevier Science B.V. All rights reser ved.