Cyclooxygenase-2 expression in the hippocampus of genetically epilepsy susceptible El mice was increased after seizure

It has been suggested that cyclooxygenase (COX)-2 and prostaglandin play a role in epilepsy. We studied the expression of COX-2 in the hippocampus and the effect of oral administration of indomethacin, a COX inhibitor, on sei zure activity in genetically seizure-susceptible El mice. COX-2 protein sig nificantly increased in the hippocampi of El mice after epileptic seizure. Indomethacin did shorten the duration from seizure onset to full recovery i n El mice although the threshold and the duration of seizure were not chang ed. (C) 2001 Elsevier Science B.V. All rights reserved.