Creutzfeldt-Jakob disease (CJD) has been considered infectious since t
he mid-1960s, but its transmissibility through the transfusion of bloo
d or blood products is controversial. The causative agent's novel unde
fined nature and resistance to standard decontamination, the absence o
f a screening test, and the recognition that even rare cases of transm
ission may be unacceptable have led to the revision of policies and pr
ocedures worldwide affecting all facets of blood product manufacturing
from blood collection to transfusion. We reviewed current evidence th
at CJD is transmitted through blood.