I. Andersson et al., Complement split products and pro-inflammatory cytokines in salvaged bloodafter hip and knee arthroplasty, CAN J ANAES, 48(3), 2001, pp. 251-255
Citations number
10
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
Purpose: To determine whether salvaged autologous blood collected postopera
tively contains complement split products (SC5b-9), and pro-inflammatory cy
tokines (IL-6 and IL-8) and whether there are any differences between blood
collected during hip or knee surgery.
Methods: Fifty-eight consecutive patients undergoing hip or knee replacemen
t surgery were studied. Thirty-eight had postoperative bleeding large enoug
h to require infusion of salvaged blood. The salvaged blood was filtered du
ring collection through a 200 mum filter and before infusion a 40 mum filte
r was used, Samples for complement and cytokine determinations were drawn f
rom the circulation and from the collected blood.
Results: High concentrations of SC5b-9, IL-6, and IL-8 were found in salvag
ed blood. The concentrations were higher than in the circulation (P < 0.05)
. The circulating concentrations of IL-6 and IL-8 were increased 60 min and
12-18 hr after transfusion. There were no differences regarding SC5b-9, IL
-6, and IL-8 in the blood collected after hip or knee surgery.
Conclusion: Blood collected from a surgical wound contains large concentrat
ions of inflammatory mediators. There were no differences between blood col
lected during hip or knee surgery.