BACKGROUND. Modern cancer treatment has increased the survival of patients
with various malignancies substantially. One of the late sequelae of succes
sful treatment is the development of a second malignant tumor. However, in
many cases of second primary tumors, exposure to chemotherapy or radiation
therapy is not evident, and it should be postulated that the putative mecha
nism for the development of the second tumor is different. In the current s
eries, the association between soft tissue sarcoma (STS) in adults and the
development of other primary malignancies was studied.
METHODS. A retrospective search of the data files of 610 patients with STS
or bone sarcomas who were treated at the study institution between January
1995 and December 1999 was performed. All files regarding patients with STS
who developed a second malignant tumor were retrieved for analysis.
RESULTS. Of 375 patients with STS, 28 (7.5%) developed other malignant neop
lasms either before or after the diagnosis of STS. STS as the first tumor o
ccurred in 14 patients (ages 16-72 years). Only three patients were treated
with chemotherapy for their sarcoma. Radiation therapy was administered to
five patients as an adjuvant to surgery for the first tumor. The second tu
mor types mainly included STS and renal cell carcinoma. The time interval b
etween the diagnosis of the STS and the second malignancy was 0 (for synchr
onous tumors) to 21 years. Three patients developed a third primary tumor w
ithin 3 years after the diagnosis of the second tumor. The median overall s
urvival was > 78 months. Fourteen patients (ages 35-87 years) had a first p
rimary tumor other than STS (mainly breast carcinoma and genitourinary mali
gnancies). The second tumors (mainly STS) appeared within 0 (for synchronou
s tumors) to 27 years. The median overall survival for the 14 patients in t
his group from the time of diagnosis of the first tumor was > 102 months.
CONCLUSIONS. The phenomenon of two or three primary neoplasms developing in
patients in whom one of the tumors was STS occurs at a rate of 7.5%, a sig
nificantly higher rate than that reported for the occurrence of STS among t
he general cancer population (1%). The majority of cases occur incidentally
. The clinical implication includes the need to search for an occult second
primary tumor in patients with STS as an integral part of their follow-up.
This is especially true in patients with primary malignant fibrous histioc
ytoma who demonstrate a risk for developing a renal cell carcinoma. (C) 200
1 American Cancer Society.