Multiple aseptic pulmonary nodules with central necrosis in association with pyoderma gangrenosum

Pulmonary manifestations of pyoderma gangrenosum are relatively rare. We re port the ease of a 45-year-old patient with multiple pulmonary nodules with central necrosis as assessed by CT scan. The patient had a 4-year history of pyoderma gangrenosum with only minor skin manifestations. A CT-guided, f ine-needle biopsy of the lung revealed a nonspecific, inflammatory, aseptic necrotic process, which was comparable to the skin biopsy of one pyoderma lesion. Following the initiation of oral prednisolone therapy, a rapid reso lution of the pulmonary nodules occurred. We conclude that pulmonary nodule s represent a rare pulmonary manifestation of pyoderma gangrenosum.