Pulmonary manifestations of pyoderma gangrenosum are relatively rare. We re
port the ease of a 45-year-old patient with multiple pulmonary nodules with
central necrosis as assessed by CT scan. The patient had a 4-year history
of pyoderma gangrenosum with only minor skin manifestations. A CT-guided, f
ine-needle biopsy of the lung revealed a nonspecific, inflammatory, aseptic
necrotic process, which was comparable to the skin biopsy of one pyoderma
lesion. Following the initiation of oral prednisolone therapy, a rapid reso
lution of the pulmonary nodules occurred. We conclude that pulmonary nodule
s represent a rare pulmonary manifestation of pyoderma gangrenosum.