Crystal structures of two new cyclosporin clathrates

Authors
Husak, M Kratochvil, B Cisarova, I Jegorov, A
Citation
M. Husak et al., Crystal structures of two new cyclosporin clathrates, COLL CZECH, 65(12), 2000, pp. 1950-1958
Citations number
10
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
65
Issue
12
Year of publication
2000
Pages
1950 - 1958
Database
ISI
SICI code
0010-0765(200012)65:12<1950:CSOTNC>2.0.ZU;2-X
Abstract
Two isomorphous clathrates formed by dihydrocyclosporin A or cyclosporin V with tert-butyl methyl ether are reported and compared with the structures of related P2(1)-symmetry cyclosporin clathrates. The cyclosporin molecules in both structures are associated via van der Waals interactions forming c avities occupied by solvent molecules (cyclosporin : tert-butyl methyl ethe r is 1 : 2).