Alkylation of heme by artemisinin, an antimalarial drug

Authors
Cazelles, J Robert, A Meunier, B
Citation
J. Cazelles et al., Alkylation of heme by artemisinin, an antimalarial drug, CR AC S IIC, 4(2), 2001, pp. 85-89
Citations number
14
Categorie Soggetti
Chemistry
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
ISSN journal
13871609 → ACNP
Volume
4
Issue
2
Year of publication
2001
Pages
85 - 89
Database
ISI
SICI code
1387-1609(200102)4:2<85:AOHBAA>2.0.ZU;2-X
Abstract
The reductive activation of artemisinin (or artemether) by ferroprotoporphy rin-IX, the prosthetic group of hemoglobin, is able to produce covalent add ucts heme-artemisinin in high yield under very mild conditions. This adduct formation, using the natural target of an endoperoxide antimalarial drug, confirms the alkylating ability of this class of antimalarial drugs, which has already been reported when using a synthetic manganese porphyrin. (C) A cademie des sciences / Editions scientifiques et medicales Elsevier SAS.