Gender- and age-related differences in corneal topography

Purpose. To investigate gender- and age-related differences in the corneal topography of a normal population. Methods. One hundred thirty-two topograp hic examinations were collected from 100 patients ranging in age from 23 to 83 years (average, 57.35 +/- 17.38 years). Data were segregated by gender and further divided into younger (less than 50 years) and older (50 years o r more) age groups. The topographic indices of Surface Regularity Index, Su rface Asymmetry Index, Irregular Astigmatism Index, Standard Deviation of C orneal Power, Corneal Eccentricity Index, Coefficient of Variation of Corne al Power, Simulated Keratometry 1 and 2, and Average Corneal Power were exa mined. The astigmatism pattern and corneal irregularity were determined and compared with respect to gender and age. Results. The corneas of older men were flatter than those of older women (p < 0.001). The vertical corneal m eridian, but not the horizontal meridian, showed statistically significant gender-related changes with aging (p < 0.001). Older men had a significantl y higher potential for against-the-rule astigmatism than women (p < 0.001). Corneal irregularity (measured in terms of the Surface Regularity Index an d Irregular Astigmatism Index) increased with age (p < 0.001 and p < 0.001, respectively), although there was no gender-related difference. In the you nger group, no gender-related differences in corneal curvature or astigmati sm pattern were found. Conclusion. Aging influences changes in patterns of astigmatism differently in men and women. Decreases in levels of sex hormon es may play a role in gender-related changes in corneal structure with age.