Optical pathology of oral tissue: A Raman spectroscopy diagnostic method

Raman and fluorescence spectroscopy methods are being considered as techniq ues which could be complementary or even alternative to biopsy, and patholo gy and clinical assays in many medical applications. The present paper disc usses the results of Raman spectral studies on oral tissues for optical pat hology. It is shown that Raman spectra of oral tissues can be classified in to spectra of normal and malignant sets and a model based on such a classif ication can be used to analyse oral tissue for detection of oral malignancy . Sensitivity and specificity calculated from 90 test spectra are better th an 85 and 90 per cent respectively.