Suspected induction of a pyoderma gangrenosum-like eruption due to sulpiride treatment

A case of a pyoderma gangrenosum (PG)-like eruption due to the antipsychoti c drug sulpiride, a form of risperidone, is described. The contribution of sulpiride to the etiology of the PG-like lesion is based on the reduction a nd healing of the ulcer upon cessation of the drug and the formation of a b ulla following the drug's re-administration. The literature on drug-induced PG or PG-like eruptions is discussed. The selectivity of sulpiride for dop amine receptors and its limited effect on other neuronal pathways different iates sulpiride from other types of antispychotic drugs commonly used in Is rael, including phenothiazine, butyrophenone, and thioxanthene. Adverse sys temic and cutaneous reactions to sulpiride and to risperidone are described . To our knowledge, this is the first report of a PG-like eruption due to t he former.