Catalytic asymmetric allylic transfer reactions for the enantioselective synthesis of dienyl and enynyl alcohols

Efficient catalytic asymmetric allylic transfer reactions of achiral aldehy des with 2-ethynyl- and 2-ethenyl-2-propenyl-stannane promoted by BINOL-Ti- IV complex with synergetic reagent are achieved for the synthesis of homoen ynyl- and dienyl alcohols with high levels of enantioselectivity. The range of enantioselectivity is 84-99% ee with good chemical yields. The applicat ion of catalytic asymmetric dienylation in a single operation was exemplifi ed by the enantioselective synthesis of naturally occurring (-)-Ipsdienol a nd (-)-Ipsenol.