We present a retrospective study evaluating the proclaimed beneficial effec
t of the use of fat grafts in patients with recalcitrant carpal tunnel synd
rome. Twenty-one re-decompression operations with fat grafting (group I) an
d 20 routine re-decompressions (group II) were assessed postoperatively wit
h a questionnaire, physical examination, and nerve conduction studies. Both
groups were improved by the operative intervention, but no significant dif
ferences were found between the two surgical techniques for postoperative s
everity of symptoms, threshold sensation, pain assessment, nerve conduction
velocities, or patients' satisfaction with the postoperative result. Only
the postoperative functional status score of the fat grafted patients revea
led a trend to a significantly worse outcome. The fat grafted patients sust
ained more problems with a hypersensitive scar at the wrist level immediate
ly after surgery, although on long-term review there was no significant dif
ference in scar tenderness between the two groups. We concluded that implan
tation of free fat grafts has not proved to be of additional benefit in pat
ients with recalcitrant carpal tunnel syndrome.